Patient compliance is high, related to the few mild side effects and once-weekly dosing. References: Webster J, et al. 1994. Comparison of cabergoline and bromocriptine in the treatment of hyperprolactinemic amenorrhea.
This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, high blood pressure ( hypertension heart valve disease.
1. J Am Geriatr Soc. 2003 Dec;51(12 1815-6. Cabergoline and silent aspiration in elderly patients with stroke. Arai T, Sekizawa K, Yoshimi N, Toshima S, Fujiwara H).
Easy to read patient leaflet for cabergoline. Includes indications, proper use, special instructions, precautions, and possible side effects.
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Get medical help right away if you have any serious side effects, including: chest pain, signs of kidney problems (such as change in the amount of urine, lower back/flank pain). A very serious allergic reaction to this drug is rare.Pregnancy: available preliminary data indicates a.
This cookie stores just a session ID; no other information is captured. Accepting the NEJM cookie is necessary to use the website.Patient compliance is high, related to the few mild side effects and once-weekly dosing. References: Webster J, et al. 1994. Comparison of cabergoline and bromocriptine in the treatment of hyperprolactinemic amenorrhea. Finally, there are data to suggest that at high doses, not usually prescribed to patients with pituitary tumors, cardiac valve dysfunction can occur. In summary, cabergoline appears to be a more effective and better tolerated dopamine agonist in the therapy of prolactinomas.
Newsletter Archive by Beverly M.K. Biller, M.D. The most interesting feature of cabergoline in terms of patient comphance is its extremely long half-life. Most patientscan be treated with a single weekly dose, is in contrast to the 1-3 times daily administration required for brornocriptine.A total of 459 women, the majority of whom had microprolactinomas or idiopathic hyperprolactinernia, were treated with either cabergoline or bromocriptine in a double blind study for 8 weeks, followed by an open label study for 16 weeks during which dose adjustments were made according.
The authors concluded that cabergoline is more effective and better tolerated than bromocriptine in women with hyperprolactinemic amenorrhea. In a United States multicenter study of patients with macroprolactinomas, we also found cabergoline to he effective and well tolerated.It is now considered first-line therapy, except in patients with contraindications, such as in women who are pregnant or desire to become pregnant, and patients with psychiatric disease. There have also been studies to suggest that in a minority of patients, impulsivity and risk-taking behaviors.
The prolactin levels decreased by 93.6 with normal levels obtained in 73 of patients at doses of mg per week. Three of 5 patients who had failed to normalize prolactin on prior dopamine agonists achieved normal levels.Seventy-two percent of cabergoline-treated women attained ovulatory cycles or became pregnant during therapy in contrast to only 52 of those treated with bromocriptine. Amenorrhea persisted in 7 of women treated with cabergoline versus 16 of women treated with bromocriptine.
Figure 1. The decline in serum prolactin level in a patient treated with cabergoline. The dotted line indicates the normal range. Webster, et al. conducted a European study comparing cabergoline to bromocriptine in the treatment of hyperprolactinemic amenorrhea.Side effects were minimal, with no patients discontinuing the medication due to intolerance. Subsequent studies have confirmed the effectiveness of cabergoline for the treatment of prolactinomas, with few side effects in most patients.
Cabergoline was better tolerated than bromocriptine with 3 of women discontinuing cabergoline versus 12 stopping bromocriptine due to intolerance. Gastrointestinal symptoms were significantly less frequent, less severe, and of shorter duration in cabergoline treated patients.N Engl J Med. Biller BMK, et al. 1996. Treatment of prolactin secreting macroadenomas with once weekly agonist cabergoline. J Clin Endocrinol Metab. Updated BS and KKM.