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Pharmacology Cabergoline, similar to bromocriptine and pergolide, is an ergot derivative doapamine receptor agonist. However, cabergoline has a greater affinity for D2 receptors in the pituitary. It is shown to be more effective than bromocriptine in inducing complete biochemical response and clinical efficacy.
Fifteen patients (8 women, 7 men) ages 18-76 years were followed in an open label, 48-week dose escalation trial of cabergoline administered once weekly. Eleven patients had received prior therapy with other dopamine agonists.
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Stimulating dopamine receptors reduces the production of the pituitary hormone prolactin, reduces the levels of growth hormone in people with acromegaly, and improves symptoms of Parkinson s. The FDA approved bromocriptine on June 28, 1978.Your doctor may start you on 0.375 mg and adjust your.
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