People with pituitary gland tumors also produce too much prolactin. Cabergoline is often used to help treat this condition. The drug is also occasionally used to help treat Parkinson s disease (a nervous system disorder that causes problems with movement, balance, and muscle control).
This generic medicine is manufactured by various pharmaceutical companies. Cabergoline Warnings Before taking cabergoline, tell your doctor if you have, or have ever had: High blood pressure Any condition that causes thickening or scarring of your heart, lungs, or abdomen.Keep all appointments with your doctor.
Interactions with Medicines. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be.Precautions.
Progestin seems to have a role in gyno development also and would warrant the use of not just an Aromatase inhibitor (AI) but also something to lower your progestin/prolactin levels like a prolactin antagonizer called Pramipexole while using compounds where things other than estrogen might.
There may be other side effects as well. You need to inform your doctor about the side effects if they persist for long. Drug Interactions: There are several medicines which may interact with the working of the medicine and thereby may cause some serious harm.Buy.
J Neurooncol. 2001;54:13950. PubMed 3. Hoffman AR, Melmed S, Schlechte J. Patient guide to hyperprolactinemia diagnosis and treatment. J Clin Endocrinol Metab. 2011;96:356. PubMed 4. Molitch ME. Pregnancy and the hyperprolactinemic woman. Cabergoline is now the first choice drug but its use in pregnancy is still under evaluation. We followed 71 term pregnancies in women bearing microprolactinomas. Of the 22 patients with previous surgery, none presented symptoms of tumor growth.
Of the 41 pregnant patients treated with bromocriptine alone, only one (2.4) presented with headaches, which regressed with drug reintroduction. Fifty one term pregnancies in patients with macroprolactinomas were followed by us.
Of those, 21 were in patients with previous surgery and none of them presented clinical evidence of tumor growth. On the other hand, of the 30 patients treated only with pre-gestational bromocriptine, 11 (37) manifested complaints related to tumor growth.
PMID : PubMed - indexed for MEDLINE. Publication Types, MeSH Terms, Substances Publication Types Review. MeSH Terms Aminoquinolines/therapeutic use Bromocriptine/therapeutic use Child. Dopamine Agonists/therapeutic use Ergolines/therapeutic use Female Humans. Magnetic Resonance Imaging Pituitary Neoplasms/drug therapy Pituitary Neoplasms/physiopathology.
Since then, dopamine agonists (DA) have been increasingly used as the first-choice treatment of prolactinomas, with surgery being reserved for resistance or persistent intolerance to DA or for special situations. More recently other DA, such as quinagolide and cabergoline have shown better tolerance than bromocriptine.
If tumor expansion is suspected, confirmation can be made through MRI and by visual field testing. Reintroduction of bromocriptine in such cases can lead to tumor reduction and clinical improvement. Surgery can also be employed as treatment for symptomatic tumor growth in pregnancy.
A comparison of cabergoline and bromocriptine in the treatment of hyperprolactinemic amenorrhea. N Engl J Med. 1994;331:9049. PubMed 8. Colao A, Di Sarno A, Sarnacchiaro S, Ferone D, DiRenzo G, Merola B, et al.
Bromocriptine as primary therapy for prolactin-secreting macroadenomas: Results of a prospective multicenter study. J Clin Endocrinol Metab. 1985;60:698705. PubMed 7. Webster J, Piscitelli G, Polli A, Ferrari CI, Ismail I, Scanlon MR.
1. Kredentser JV, Hosking CF, Scott JZ. Hyperprolactinoma - A significant factor in female infertility. Am J Obstet Gynecol. 1981;139:2647. PubMed 2. Nomikos P, Buchfelder M, Fahlbusch R. Current management of prolactinomas.
Paulo, SP, Brazil. Abstract Prolactinomas are the most frequent pituitary tumors. Treatment of infertility in such tumors usually is very successful. On the other hand, reports of pituitary tumor growth during pregnancy have been described since bromocriptine started to be used.