Cabergoline lactation inhibition

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Cabergoline lactation inhibition

Posted Mar 16, 2016 by Admin

Puerperal thromboembolism and suppression of lactation. Lancet. 1967 Aug 5;2(7510 287289. PubMed Tindall VR. Factors influencing puerperal thrombo-embolism. J Obstet Gynaecol Br Commonw. 1968 Dec;75(12 13241327. PubMed Rolland R. Use of bromocriptine in the inhibition of puerperal lactation.Single doses of cabergoline produce a prolactin-lowering effect, usually within 3 hours of drug administration, which may persist for at least 21 days in puerperal women. Higher doses produce a more rapid decline in plasma prolactin levels and the rate of reduction may determine the. Long-lasting prolactin-lowering effect of cabergoline, a new dopamine agonist, in hyperprolactinemic patients. J Clin Endocrinol Metab. 1986 Oct;63(4 941945. PubMed Melis GB, Mais V, Paoletti AM, Beneventi F, Gambacciani M, Fioretti P.

PubMed MANTEL N, HAENSZEL W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959 Apr;22(4 719748. PubMed Articles from The BMJ are provided here courtesy of BMJ Group).In the prevention of puerperal lactation, a single dose of cabergoline 1.0mg is recommended. The drug should be taken as soon as possible, and preferably within the first 24 hours after parturition, to maximise response.

Last Updated on eMC 23-Dec-2013 View changes Pfizer Limited. Contact details Address Ramsgate Road, Sandwich, Kent, CT13 9NJ. Fax 44 (0) Telephone 44 (0) Medical Information Website.uk.At this stage of its development, cabergoline will prove useful in patients with hyperprolactinaemia who have failed treatment with, or are intolerant of, other dopamine agonists such as bromocriptine. If drug treatment is required for the prevention or suppression of puerperal lactation, cabergoline offers significant.

Agonist activity at this receptor on the lactotroph results in inhibition of prolactin secretion. Cabergoline has profound prolactin-lowering effects in animals, healthy volunteers, patients with hyperprolactinaemia and puerperal women. These effects are dose-dependent in humans within the range 0.2 to 1.0mg, both in terms of.Galactorrhoea, which was present in some women at study entry, was alleviated in 90 and 78 of women, respectively. Long term efficacy studies have demonstrated the continued therapeutic effects of cabergoline after drug withdrawal.

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BMJ. 1991 Jun 8; 302(6789 13671371. PMCID : PMC1670075 Copyright and License information Copyright notice. Abstract OBJECTIVE -To compare the efficacy and safety of a single dose of 1 mg of cabergoline with that of bromocriptine 2.5 mg twice daily for 14 days in the.Although there are no published studies on the use of cabergoline for the suppression of established puerperal lactation, a dose schedule of 0.25mg twice daily for 2 days has been suggested as the most appropriate for this indication.

Selected References These references are in PubMed. This may not be the complete list of references from this article. Kochenour NK. Lactation suppression. Clin Obstet Gynecol. 1980 Dec;23(4 10451059. PubMed Daniel DG, Campbell H, Turnbull AC.Cabergoline appears to be well tolerated by most patients intolerant of other dopaminergic ergot derivatives, including bromocriptine. Dosage and Administration The recommended dosage of cabergoline in patients with hyperprolactinaemic disorders is 0.5 to 1.0mg twice weekly.

In the only comparative study to date, cabergoline 0.5 to 1.0mg twice weekly was more effective than bromocriptine 2.5 to 5.0mg twice daily in the treatment of hyperprolactinaemic amenorrhoea, restoring ovulatory cycles in 72 of women and normalising plasma prolactin levels in 83, compared with.INTERVENTIONS -Women randomised to cabergoline received two 0.5 mg tablets of cabergoline and one placebo tablet within 27 hours after delivery and then placebo twice daily for 14 days. Those randomised to bromocriptine received 2.5 mg of bromocriptine and two placebo tablets within 27 hours.

The adverse events noted with cabergoline are characteristic of the dopaminergic ergot derivatives. The most commonly reported include nausea/vomiting (35 headache/migraine (30) and dizziness/vertigo (25). Measurable falls in blood pressure occur in up to 50 of patients taking cabergoline but are rarely symptomatic.Large prolactinomas can also result in headaches and visual field defects. Prolactin stimulates postpartum milk production. Although other hormones are involved, galactopoiesis cannot occur without prolactin. Inhibition of puerperal lactation may be desirable because of medical conditions, in either mother or infant, or through personal.

A dose of 0.25mg twice daily for 2 days is suggested for the suppression of established puerperal lactation. This regimen has been found to be effective while maximising tolerability. Various sections of the m.The effects on prolactin persist for some time after drug withdrawal, with normoprolactinaemia evident for up to 2 years after discontinuation of cabergoline in some patients. In patients with hyperprolactinaemia or puerperal women, cabergoline does not appear to affect endocrine function other than prolactin, although.

Bromocriptine mesylate for prevention of postpartum lactation. Obstet Gynecol. 1981 Apr;57(4 464467. PubMed Crosignani PG, Lombroso GC, Caccamo A, Reschini E, Peracchi M. Suppression of puerperal lactation by metergoline. Obstet Gynecol.Dopamine is believed to be the major prolactin inhibiting factor and ergot derivatives which show dopaminergic properties have been used as hypoprolactinaemic agents since the 1970s. Pharmacological Properties Cabergoline has a high selectivity and affinity for the dopamine D2 receptor.