Patient compliance is high, related to the few mild side effects and once-weekly dosing. References: Webster J, et al. 1994. Comparison of cabergoline and bromocriptine in the treatment of hyperprolactinemic amenorrhea.
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Abstract Send to: See comment in PubMed Commons below. Pituitary. 2010 Dec;13(4 345-50. doi: 10.1007/s1. Stalldecker G 1, Mallea-Gil MS, Guitelman M, Alfieri A, Ballarino MC, Boero L, Chervin A, Danilowicz K, Diez S, Fainstein-Day P, Garca-Basavilbaso N, Glerean M, Gollan V, Katz D, Loto.Liver.
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Stimulating dopamine receptors reduces the production of the pituitary hormone prolactin, reduces the levels of growth hormone in people with acromegaly, and improves symptoms of Parkinson s. The FDA approved bromocriptine on June 28, 1978.Your doctor may start you on 0.375 mg and adjust your.
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The best results come from surgeons who have performed many hundreds or even thousands of such operations. Autopsy studies indicate that 25 percent of the U.S. population have small pituitary tumors. Forty percent of these pituitary tumors produce prolactin, but most are not considered clinically significant. Clinically significant pituitary tumors affect the health of approximately 14 out of 100,000 people.
This type of drug is called a dopamine agonist. These drugs shrink the tumor and return prolactin levels to normal in approximately 80 of patients. Both have been approved by the Food and Drug Administration for the treatment of hyperprolactinemia.
In women, high levels of prolactin in the blood often cause infertility and changes in menstruation. In some women, periods may stop. In others, periods may become irregular or menstrual flow may change.
Prolactin levels rise again in most people when the drug is discontinued. In some, however, prolactin levels remain normal, so the doctor may suggest reducing or discontinuing treatment every 2 years on a trial basis.
Hypothyroidism. Increased prolactin levels are often seen in people with hypothyroidism, a condition in which the thyroid does not produce enough thyroid hormone. Doctors routinely test people with hyperprolactinemia for hypothyroidism.
People taking cabergoline who develop symptoms of shortness of breath or swelling of the feet should promptly notify their phy.
Because the results of surgery are so dependent on the skill and knowledge of the neurosurgeon, a patient should ask the surgeon about the number of operations he or she has performed to remove pituitary tumors, and for success and complication rates in comparison to.
As with bromocriptine therapy, nausea and dizziness are possible side effects but may be avoided if treatment is started slowly. The usual starting dose is.25 mg twice a week. The dose may be increased every 4 weeks as needed, up to 1 mg two times.
Points to Remember Clinical Trials What is a prolactinoma? A prolactinoma is a benign noncancerous tumor of the pituitary gland that produces a hormone called prolactin. Prolactinomas are the most common type of pituitary tumor.
Although small benign pituitary tumors are fairly common in the general population, symptomatic prolactinomas are uncommon. Prolactinomas occur more often in women than men and rarely occur in children. Top What are the symptoms of prolactinoma?
Pituitary tumors may also impair production of one or more pituitary hormones, causing reduced pituitary function, also called hypopituitarism. The pituitary gland sits in the sella turcica. Top How common is prolactinoma?
These drugs include older antipsychotic medications such as trifluoperazine (Stelazine) and haloperidol (Haldol the newer antipsychotic drugs risperidone (Risperdal) and molindone (Moban metoclopramide (Reglan used to treat gastroesophageal reflux and the nausea caused by certain cancer drugs; and less often, verapamil, alpha-methyldopa (Aldochlor, Aldoril and.