Cabergoline treatment acromegaly

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Cabergoline treatment acromegaly

Posted Mar 04, 2016 by Admin

Radiation therapy causes a gradual loss of pituitary hormone levels over time, resulting in hypopituitarism. Loss of vision and brain injury, which have been reported, are very rare complications of radiation treatments.By Mayo Clinic Staff Print Acromegaly is a hormonal disorder that develops when your pituitary gland produces too much growth hormone during adulthood. When this happens, your bones increase in size, including those of your hands, feet and face. This follow-up care may last for the rest of your life. Diagnosis Clinical trials Jan. 16, 2016 Print. Share on: Facebook References AskMayoExpert. Acromegaly and gigantism. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2014.

A brain MRI should be performed to locate the tumor and confirm the diagnosis.  In most cases of acromegaly, a benign pituitary macroadenoma (greater than 10 mm) is found. Therapy Surgery Surgery is a rapid and effective treatment.3, 2015. Cabergoline (prescribing information). North Wales, Penn.: Teva Pharmaceuticals USA, Inc.; 2015. m/product/cabergoline-tablets. Accessed Dec. 3, 2015. Nippoldt, TB (expert opinion). Mayo Clinic, Rochester, Minn. Dec. 23, 2015. Acromegaly Overview Symptoms causes Diagnosis treatment.

It is unclear whether these findings are relevant in subjects with acromegaly who take cabergoline. A. Growth Hormone Receptor Antagonist (GH), pegvisomant (Somavert is a novel approach to acromegaly treatment by blocking all peripheral effects of GH, resulting in decreased production of IGF-1, both locally.Stereotactic radiosurgery. Also known as Gamma Knife radiosurgery, stereotactic radiosurgery can deliver a high dose of radiation to the tumor cells in a single dose while limiting the amount of radiation to the normal surrounding tissues.

You administer this medication yourself daily by subcutaneous injection. This medication can normalize IGF-I levels and relieve symptoms in most people with acromegaly, but doesn't lower GH levels or reduce the tumor size.Drugs used to lower the production or block the action of GH include: Somatostatin analogues. The drugs octreotide (Sandostatin) and lanreotide (Somatuline Depot) are synthetic versions of the brain hormone somatostatin.

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Outpatient Clinical Visits: (650) Physician Referrals Questions: (800) Email: Diagnosis Once acromegaly is suspected, diagnosis is straightforward. An elevated serum insulin-like growth factor -1 (IGF-1 in the appropriate clinical setting, is adequate for the diagnosis of acromegaly.Px. Accessed Dec. 3, 2015. Papadakis MA, et al., eds. Diseases of the hypothalamus pituitary gland. In: Current Medical Diagnosis Treatment 2015. 54th ed. New York, N.Y.: The McGraw-Hill Companies; 2015.

Because acromegaly is uncommon and physical changes occur gradually, the condition often isn't recognized immediately: sometimes not for years. If not treated promptly, acromegaly can lead to serious illness and even become life-threatening.The surgeon reaches the pituitary through an incision in the nose and, with special tools, removes the tumor tissue in a procedure called transsphenoidal surgery.  The goal is to remove or debulk the tumor. 

Acromegaly is a rare disorder resulting from a pituitary tumor that overproduces growth hormone (GH). The physical changes may be disfiguring (enlarged nose, lips, hands, feet) and uncomfortable (excess sweating, headaches, dizziness, arthritis).Early diagnosis and appropriate therapy may lead to reversal and/or prevention of these long-term consequences. Treatment at Stanford Patients can receive an evaluation and treatment for acromegaly at the Stanford Pituitary Center.

Surgery Doctors can remove most pituitary tumors using a method called transsphenoidal surgery. In this procedure, your surgeon works through your nose to extract the pituitary tumor. Removing the tumor can normalize GH production and eliminate the pressure on the tissues surrounding your pituitary gland.Acromegaly and gigantism. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2014. Melmed S. Causes and clinical manifestations of acromegaly. m/home. Accessed Dec. 3, 2015. Acromegaly. National Institute of Diabetes and Digestive and Kidney Diseases.

Pegvisomant, administered as a daily, biweely, or weekly subcutaneous injection, can be used in patients who do not respond to somatostatin analogs or other types of treatment or may be considered as first line therapy in selected patients.Diseases of the hypothalamus pituitary gland. In: Current Medical Diagnosis Treatment 2015. 54th ed. New York, N.Y.: The McGraw-Hill Companies; 2015. m. Accessed Dec. 3, 2015. Parlodel (prescribing information). Parsippany, New Jersey: Validus Pharmaceuticals LLC; 2015.

Combination Therapy In patients who are partially responsive to somatostatin analogs, further benefit can be achieved by adding either a dopamine agonist, such as cabergoline, or pegvisomant. Radiation Therapy Radiation therapy for acromegaly is usually reserved for patients who have tumor remaining after surgery, and.Melmed S. Causes and clinical manifestations of acromegaly. m/home. Accessed Dec. 3, 2015. Acromegaly. National Institute of Diabetes and Digestive and Kidney Diseases. px. Accessed Dec. 3, 2015. Papadakis MA, et al., eds.