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The control group comprised of 25 historical cases, which were similar to the case group. The latter group did not receive cabergoline, and their OHSS, if occurred, were managed conservatively after hospital admission. The rates of OHSS, baseline characteristics, ovarian stimulation parameters, and pregnancy occurrence were compared. There was no significant difference between baseline characteristics or ovarian stimulation parameters form the two groups. The incidence of OHSS in the cabergoline-treated group, was significantly (P0.01) lower than that in.
Standard treatments for OHSS are generally conservative, and potentially life-threatening complications of OHSS, which require costly long-term hospitalizations, render prophylactic measures a must., Some approaches, which are based on the pathophysiology of OHSS, are now applied for its prevention.
Recent findings have identified vascular endothelial growth factor (VEGF ) as the major molecule responsible for increased capillary permeability. The production of VEGF in ovarian follicles increases during stimulation period, and results in a rapid increase in vascular permeability upon binding to type 2 VEGF.
All PCOS patients were treated with metformin (1500 mg/day). Few of the patients had positive history of OHSS, regardless of its severity. All of the participants underwent controlled ovarian hyperstimulation (COH) with Gonadotropin/GnRH-agonist long protocol.
The inclusion criteria were an age of less than 33 years, high risk of developing OHSS in the absence of taking antipsychotic medications, no known allergy to cabergoline or ergot alkaloids, and absence of hepatic dysfunction or hypertension.
Metabolic features of PCOS patients were not of concern in this study; therefore, insulin resistance and androgen index were not measured. The oligomenorrhea/amenorrhea and polycystic appearance of ovaries were seen in more than two third of the PCOS patients.
Iran J Med Sci. 2011 Sep; 36(3 207212. PMCID : PMC3556762 Marzieh Agha Hosseini,1 Ashraf Aleyasin,1 Atossa Mahdavi,1 Romina Nezami,1 Leila Safdarian,1 and. Parvin Fallahi 2 Author information Article notes Copyright and License information Received 2010 Aug 4; Revised 2010 Oct 30; Accepted 2011 Feb.
Patients were followed until the detection of fetal heart rate. Abortion).
The latter group did not receive cabergoline, and their OHSS, if occurred, were. Standard treatments for OHSS are generally conservative, and potentially.
Luteal phase support was started the day after ovum pick up by the administration of progesterone suppository Cyclogest (Actavis, UK) at 800 mg/day. The participants were divided in two groups. The first group (intervention or case group) comprised 50 women treated with 1 mg of.
Long term desensitization protocol using subcutaneous GnRH agonist Buserelin (500 g) was started on the day 21 of the previous cycle. After complete desensitization, ovarian stimulation using recombinant-FSH (Gonal F, Serono, switzerland) was commenced on day 3 of the next cycle at a daily dose.
The study included an intervention and a control group. The intervention group comprised of 50 women at risk of OHSS, who were treated with cabergoline (1 mg every other day for 8 days) commencing from the day of ovum pick up.
Polycystic ovarian syndrome was diagnosed according to Rotterdam criteria. According to the Rotterdam criteria, patients with two of the three characteristics including: 1) oligomenorrhea/amenorrhea, 2) clinical (hirsutism) finding of hyperandrogenism, or 3) polycystic ovaries on transvaginal sonography, were included in the study.