Comparison cabergoline bromocriptine treatment hyperprolactinemic amenorrhea

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    Stimulating dopamine receptors reduces the production of the pituitary hormone prolactin, reduces the levels of growth hormone in people with acromegaly, and improves symptoms of Parkinson s. The FDA approved bromocriptine on June 28, 1978.Your doctor may start you on 0.375 mg and adjust your.

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Comparison cabergoline bromocriptine treatment hyperprolactinemic amenorrhea

Posted Mar 05, 2016 by Admin

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Section of Endocrinology, Metabolism, and Diabetes, University of Wales College of Medicine, Cardiff, United Kingdom. BACKGROUND : Cabergoline is a long-acting dopamine-agonist drug that suppresses prolactin secretion and restores gonadal function in women with hyperprolactinemic amenorrhea.

We designed a study to compare its safety and efficacy with those of bromocriptine, which has been the standard therapy. METHODS : A total of 459 women with hyperprolactinemic amenorrhea were treated with either cabergoline (0.5 to 1.0 mg twice weekly) or bromocriptine (2.5 to.

A comparison of cabergoline and bromocriptine in the treatment of hyperprolactinemic amenorrhea. Cabergoline Comparative Study Group. N Engl J Med. 1994; 331(14 904-9 (ISSN : ) Webster J; Piscitelli G; Polli A; Ferrari CI; Ismail I; Scanlon MF.

Gastrointestinal symptoms were significantly less frequent, less severe, and shorter-lived in the women treated with cabergoline. CONCLUSIONS : Cabergoline is more effective and better tolerated than bromocriptine in women with hyperprolactinemic amenorrhea.

Side effects of cabergoline 0 5

Amenorrhea persisted in 7 percent of the cabergoline-treated women and 16 percent of the bromocriptine-treated women. Adverse effects were recorded in 68 percent of the women taking cabergoline and 78 percent of those taking bromocriptine (P 0.03 3 percent discontinued taking cabergoline, and 12 percent.

RESULTS : Stable normoprolactinemia was achieved in 186 of the 223 women treated with cabergoline (83 percent) and 138 of the 236 women treated with bromocriptine (59 percent, P 0.001). Seventy-two percent of the women treated with cabergoline and 52 percent of those treated with.

From MEDLINE /PubMed, a database of the U.S. National Library of Medicine.

1999;84:251822. PubMed 3. Corsello SM, Ubertini G, Altomare M, Lovicu RM, Migneco MG, Rota CA, et al. Giant prolactinomas in men: efficacy of cabergoline treatment. Clin Endocrinol (Oxf) 2003;58:66270. PubMed 4.

A blood test can show whether your prolactin level is higher than normal. If its borderline, you may be tested twice to be sure. Your doctor may also give you a physical exam and order an MRI to get an image of your brain.

Ask your pharmacist if you have questions about which medicines may cause drowsiness. Amitriptyline/perphenazine may cause dizziness, light-headedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning.

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Cabergoline is a dopamine receptor agonist. It works by reducing the amount of prolactin (a hormone) that is released from the pituitary gland.