Dose of cabergoline to suppress lactation

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    The practitioner may suggest cardiovascular evaluation and echocardiography to evaluate valvular disease before recommending this drug. Use of this drug is not suggested to those suffering from uncontrolled hypertension or known hypersensitivity to ergot derivatives, pregnancy-induced hypertension, for example, preeclampsia, eclampsia, and post partum hypertension.

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    Cabergoline (name brands Dostinex and Cabaser) is a dopamine receptor agonist and uncategorized drug which suppresses the production of prolactin in pituitary gland. It is an ergot-derivative. GoldBamboo. Cabergoline (Dostinex) is used to treat high levels of prolactin, a hormone made by the body that.Cabergoline.

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Dose of cabergoline to suppress lactation

Posted Mar 03, 2016 by Admin

1991;. PMID :. European Multicentre Study Group for Cabergoline in Lactation Inhibition. Single dose cabergoline versus bromocriptine in inhibition of puerperal lactation: randomised, double blind, multicentre study. Br Med J. 1991;. Only 1 of 8 women receiving placebo had cessation of lactation by day 14 postpartum. Serum prolactin levels collected on days 2, 3 and 4 of treatment were decreased significantly in all women who received cabergoline, but the decreases were not statistically different among the.

Cabergoline was at least as effective as bromocriptine, with complete success in 78 of cabergoline patients and 69 of bromocriptine patients. The rate of rebound lactation was much higher in bromocriptine patients (24) than in cabergoline patients (5).

Lactation was completely inhibited in 92 of women; 8 women required a second doses of 1 mg to inhibit lactation. Twenty-six percent of women had side effects such as dizziness, headache, nausea and abdominal pain.

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The 1 mg dose was more effective in suppressing lactation than the 0.5 mg dose. Headache and nausea were the most common adverse effects.10 A follow-up survey was conducted on 91 women who became pregnant after treatment with cabergoline for hyperprolactinemia from pituitary adenomas.

If it is necessary, the dosage may be increased depending on the therapeutic effect and its tolerability. The increasing of the weekly dose should be done gradually (500 mg at intervals with 1 month).

PMID :. Bracco PL, Armentano G, Pellegrini A et al. Cabergoline in the inhibition of lactogenesis and suppression of lactopoiesis. Minerva Ginecol. 1997;. PMID :. Pavlista D, Calda P, Zivny J.

Serum prolactin levels collected during 13 days of treatment were decreased significantly in all women who received cabergoline, but the decreases were not statistically different among the various doses. Adverse effects included occasional dizziness and headache between days 1 and 3 after the dose.5 In.