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Bromocriptine was discontinued at 6 weeks gestation when pregnancy was confirmed. A PRL concentration was 1899 microg/L (non-pregnant normal range microg/L, the mean peak levels during pregnancy reported from the literature are 200-210 microg/L) at 7 weeks gestation, and a repeat was 2197 microg/L.
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Serum IGF1 and prolactin were estimated on each occasion. Biochemical remission was defined as serum GH 5mU/l. PATIENTS : Eleven acromegalics were investigated. Previous treatment included surgery (7 radiotherapy (5) and bromocriptine (5).Three patients had not received any previous treatment. All had random GH persistently.
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