Quinagolide vs cabergoline

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Quinagolide vs cabergoline

Posted Mar 06, 2016 by Admin

After CAB treatment, further tumour shrinkage ranging 4-40 and 2-70 was observed in 12 micro- and seven macroprolactinomas, respectively. The percentage of tumour shrinkage after CAB was significantly higher than that observed after quinagolide in microprolactinomas (48.6 /- 9.5 vs.This cookie stores just a session ID; no other information is captured. Accepting the NEJM cookie is necessary to use the website. A wash-out period was performed in all patients after 12 months of both treatments in order to evaluate recurrence of hyperprolactinaemia. PATIENTS : Twenty-three patients with microprolactinoma (basal serum PRL levels mU/l) and 16 patients with macroprolactinoma (basal serum PRL levels mU/l previously shown to.

Tumour shrinkage was recorded in 22-25 of patients after quinagolide and in 30-31 after CAB treatment.None of the 39 patients reported side-effects during CAB treatment. CONCLUSIONS : Both quinagolide and CAB treatments, induced the normalization of serum PRL levels in the great majority of patients with prolactinoma.

2636.1 /- 262.3 mU/l, P 0.006) and in macroprolactinomas (24853.1 /- 7566.7 vs. 3576.6 /- 413.0 mU/l, P 0.013). After 12 months of CAB treatment, serum PRL levels normalized in 22 out of 23 patients with microprolactinoma (95.6) and in 14 out of 16 with.In the remaining four patients serum PRL levels remained normal after 12 months of CAB withdrawal. Both compounds were tolerated satisfactorily by all patients. In the first week of quinagolide treatment, 12 patients reported nausea and postural hypotension, which spontaneously disappeared during the second-third week.

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OBJECTIVE : To compare effectiveness and tolerability of quinagolide (CV 205-502) and cabergoline (CAB) treatments in 39 patients with prolactinoma. STUDY DESIGN : All 39 patients were treated first with quinagolide for 12 months and then with cabergoline for 12 months.All patients had recurrence of hyperprolactinaemia after 15-60 days withdrawal of quinagolide treatment. However, before starting CAB treatment basal PRL levels were significantly lower than before quinagolide treatment both in microprolactinomas (4667.4 /- 714.7 vs.

26.7 /- 4. 5, P 0.046) but not in macroprolactinomas (47.0 /- 10.6 vs. 26.8 /- 8.4, P 0.2). The withdrawal from CAB treatment, induced an increase in serum PRL levels in all macroprolactinomas between 15 and 30 days, in 15 out of 23 microprolactinoma.No difference in PRL nadir was found after quinagolide and CAB treatments both in micro 174.6 /- 30.6 vs. 169.8 /- 37.9 mU/l, P 0.5) and in macroprolactinomas (277.5 /- 68.4 vs.

All patients had gonadal failure and 11 patients with macroprolactinoma had visual field defects. Five patients with macro- and one with microprolactinoma had previously undergone surgery. STUDY PROTOCOL : The starting doses of quinagolide and CAB were 0.075 mg/day and 0.5 mg/week, respectively, subsequently increased.Our apologies. An error occurred while setting your user cookie. Please set your browser to accept cookies to continue. NEJM. org uses cookies to improve performance by remembering your session ID when you navigate from page to page.

Tumour shrinkage was evaluated by serial magnetic resonance imaging (MRI) studies of the hypothalamus-pituitary region at study entry and after 6 and 12 months of both treatments in micro- and macroprolactinomas.