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What do we do with the patient with a prolactinoma who is resistant or only partially responsive to a dopamine agonist? Fortunately, this is an infrequent problem.
Stimulating dopamine receptors reduces the production of the pituitary hormone prolactin, reduces the levels of growth hormone in people with acromegaly, and improves symptoms of Parkinson s. The FDA approved bromocriptine on June 28, 1978.Your doctor may start you on 0.375 mg and adjust your.
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Figure 1. The decline in serum prolactin level in a patient treated with cabergoline. The dotted line indicates the normal range. Webster, et al. conducted a European study comparing cabergoline to bromocriptine in the treatment of hyperprolactinemic amenorrhea. Ask your health care provider if cabergoline may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about cabergoline. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse.
Side effects were minimal, with no patients discontinuing the medication due to intolerance. Subsequent studies have confirmed the effectiveness of cabergoline for the treatment of prolactinomas, with few side effects in most patients.
Cabergoline was better tolerated than bromocriptine with 3 of women discontinuing cabergoline versus 12 stopping bromocriptine due to intolerance. Gastrointestinal symptoms were significantly less frequent, less severe, and of shorter duration in cabergoline treated patients.
N Engl J Med. Biller BMK, et al. 1996. Treatment of prolactin secreting macroadenomas with once weekly agonist cabergoline. J Clin Endocrinol Metab. Updated BS and KKM.
It may also be used for other conditions as determined by your doctor. Cabergoline is a dopamine receptor agonist. It works by blocking prolactin secretion from the pituitary gland. Do NOT use cabergoline if: you are allergic to any ingredient in cabergoline or to ergot.
It is now considered first-line therapy, except in patients with contraindications, such as in women who are pregnant or desire to become pregnant, and patients with psychiatric disease. There have also been studies to suggest that in a minority of patients, impulsivity and risk-taking behaviors.
Check with your doctor or pharmacist if you are unsure if any of your medicines may lower blood pressure or cause heart valve problems. Some MEDICINES MAY INTERACT with cabergoline. Tell your health care provider if you are taking any other medicines, especially any of.
The authors concluded that cabergoline is more effective and better tolerated than bromocriptine in women with hyperprolactinemic amenorrhea. In a United States multicenter study of patients with macroprolactinomas, we also found cabergoline to he effective and well tolerated.
It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider.
This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using cabergoline.
Cabergoline is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor.
The prolactin levels decreased by 93.6 with normal levels obtained in 73 of patients at doses of mg per week. Three of 5 patients who had failed to normalize prolactin on prior dopamine agonists achieved normal levels.